Spravato (esketamine) is a groundbreaking treatment for individuals with treatment-resistant depression (TRD) and major depressive disorder with suicidal ideation (MDSI). Unlike traditional antidepressants, Spravato works rapidly, often providing symptom relief within hours. In this article, we’ll introduce Spravato, discuss how long it takes to work, and explore its short- and long-term effects.
Spravato (esketamine) is an FDA-approved nasal spray derived from ketamine, specifically designed to treat individuals with TRD and MDSI.
Like ketamine, Spravato works by inhibiting NMDA receptors—proteins involved in learning and memory. This inhibition leads to the release of glutamate, a key neurotransmitter, triggering several downstream effects in brain cells.
Unlike standard antidepressants, Spravato has rapid-acting effects, sometimes appearing almost immediately after use. It also offers sustained benefits compared to conventional medications and doesn’t require daily use.
Spravato enhances activity in brain regions responsible for mood regulation, which are often underactive in depression. This effect can occur within hours, often within 24 hours, leading to symptom relief and an improved mood.
Over time, repeated doses of Spravato strengthen connections between nerve cells through neuroplasticity. Spravato stimulates the production of proteins that support this process, reinforcing neural circuits linked to mood and emotional regulation. Neuroplasticity may explain Spravato’s prolonged improvements in depression.
Clinical trials have shown that Spravato can quickly reduce symptoms of depression, often within hours or days.
In a study of adults with TRD, those who took Spravato along with an antidepressant experienced noticeable symptom relief within 24 hours—an improvement greater than those who took a placebo with an antidepressant. Both groups continued improving over the next 28 days, but the difference between them remained significant.
For people with MDSI, clinical
studies have shown that Spravato, combined with an antidepressant, significantly reduces symptoms within 24 hours compared to placebo groups. The greatest differences are seen within four hours of taking the medication.
The time it takes for Spravato to start working varies from person to person. Some may feel relief within hours, while others may require several treatments over days or weeks to notice significant changes. Factors that influence how quickly Spravato works include:
How Long Do the Effects of Spravato Last?
A single dose of Spravato provides relief for up to 24 hours, but for sustained benefits, treatment follows a structured regimen:
A long-term
study found that
35.6% of patients achieved remission after the induction phase, and
46.1% remained in remission during the maintenance phase. On average, patients in the maintenance phase had used Spravato for just over three years, indicating its continued benefits with long-term use.
While Spravato is generally well tolerated, mild side effects are common, including:
These side effects typically wear off within a few hours but can linger for up to 24 hours.
Ketamine is a drug of abuse with addictive properties. Chronic misuse has been linked to long-term effects such as cognitive impairment and damage to the bladder, liver, and kidneys.
However, Spravato is administered in a controlled clinical environment, significantly reducing the risk of misuse. While it has not been extensively studied in patients with pre-existing substance abuse disorders, those with addiction histories may be at higher risk.
Physically, Spravato appears safe for long-term use, though some evidence suggests users may experience bladder-related symptoms. However, clinical trials have found no significant difference in bladder infections between Spravato and non-Spravato patients.
At Southwest Florida TMS & Ketamine Clinic, we specialize in innovative depression treatments, including Spravato therapy for individuals with TRD. If you’re struggling with depression and haven’t found relief from conventional therapy, our services, based in Fort Myers, could have the solution you need. Spravato is a fast-acting medication with sustained benefits, and our team is highly experienced in delivering this medicine with expert care.
If you choose to have treatment at our service, we will closely monitor you during and after administration and will be here to provide support after and between doses.
For more information on Spravato treatment and to schedule a consultation, visit our Spravato Clinic page.
Expert Care at SW Florida TMS & Ketamine Clinic: Offering specialized Spravato therapy with close monitoring and personalized treatment plans for patients with TRD.
Knowing that you are not alone is of utmost importance. Seek assistance for depression today!
The TMS and Ketamine Clinic of Southwest Florida is deeply committed to your mental well-being. Whether you're a Fort Myers resident or commuting from the surrounding area, our experienced psychiatrist and trained mental health professionals are here to guide you toward a life of clarity and purpose. Many of our FDA-cleared mental health treatments, including TMS therapy, Ketamine infusion therapy, and SPRAVATO® esketamine treatment, are non-invasive and covered by insurance, ensuring accessible depression and anxiety treatment for those in need.
CareCredit is a health and wellness credit card that provides flexible financing options, allowing you to pay over time for the care you desire or require. Accepted at more than 260,000 locations, we are delighted to provide CareCredit to individuals in need of financial support for their TMS or Ketamine treatment. If you have any questions, please reach out to one of our team members for additional details. Also, you can easily scan the QR code displayed here to prequalify or conveniently pay your bill online.
All Rights Reserved | SW Florida TMS